“Opioids and the gut”

This PowerPoint presentation describes how opioids cause a reduction in neuronal excitability and inhibition of neurotransmitter release1–3.

Because some opioid receptors are present in peripheral tissues3, laxatives provide no or partial relief for patients with chronic OIC, as they don’t target the underlying pathophysiology2,4,5.

“OIC and opioid adherence”

This PowerPoint presentation reveals how OIC is the most common and bothersome adverse event affecting patients on long-term opioid treatment2.

Studies show that OIC interferes with patients’ pain management and their adherence to opioid treatment6,7. While common laxatives may offer some symptomatic relief, they have limited efficacy as they do not target the underlying pathophysiology of OIC2,4,8.

“Barriers to communication”

This PowerPoint presentation shows, that as a result of their OIC symptoms, patients also experience a significant psychosocial impact on their lives.

Patients may struggle to communicate their symptoms which can led to a disconnect between patient experience and physician perception9,10.  However, there are clinically available tools and assessments to help the diagnosis of OIC and facilitate conversations with patients8,11–13*


  1. Chahl LA. Aust Prescr 1996;19:63–5
  2. Bell TJ, et al. Pain Med 2009;10:35–42
  3. Trescot AM, et al. Pain Phys 2008;11:S133–53
  4. Rumman A, et al. Exp Rev Quality Life Cancer Care 2016;1:25–35
  5. Coyne KS, et al. Clinicoecon Outcomes Res 2014;6:269–81
  6. Hjalte F, et al. J Pain Sympt Manag 2010;40:696–703
  7. Kurz A, Sessler DI. Drugs 2003;63:649–71
  8. Nelson AD, Camilleri M. Therap Adv Gastroenterol 2015;8:206–20
  9. LoCasale RJ, et al. J Manag Care Spec Pharm 2016;22:236–45
  10. Rauck RL, Pain Pract 2017;17:329–35
  11. Gaertner, J et al. J Clin Gastroenterol 2015;49:9–16
  12. Lewis SJ, Heaton KW. Scand J Gastroenterol 1997;32:920–24
  13. Frank L et l. Scand J Gastroentrol 1999;34:870–7

*For use in both clinical trials and general clinical practice.